Krisztián Koós

LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis

This study shows that LBR and LAP2 tether heterochromatin to the nuclear periphery, and their loss disrupts genome homeostasis by repositioning heterochromatin and altering gene expression.

A Morpho-Proteomic Atlas of Mitosis at Sub-Minute Resolution

This study creates a high-resolution morpho-proteomic atlas of mitosis by decomposing it into 40 subsections and quantifying 4,350 proteins, revealing dynamic changes and links to cancer mutations.

Automatic deep learning driven label-free image guided patch clamp system for human and rodent in vitro slice physiology

The paper develops an automated patch clamp system using deep learning and image analysis to measure neurons in human and rodent brain slices.

Cell-type specific arousal-dependent modulation of thalamic activity in the lateral geniculate nucleus

This study shows that LGN neurons in awake mice have arousal-dependent activity linked to pupil size and corticothalamic feedback, forming distinct coalitions between thalamocortical neurons and interneurons.

A deep learning framework for nucleus segmentation using image style transfer

The paper introduces a deep learning framework for nucleus segmentation that uses image style transfer to adapt to new data without expert annotations, outperforming existing methods on diverse microscopy images.