Veena Mathew

The paper identifies DNA2 nuclease activity as a preferred therapeutic target in cancer by showing its essential role in DNA repair and fitness, with specific sensitivity in ALT+ tumors.

This study shows that Cdc48 regulates the deposition of the splicing factor Hsh155 at intranuclear quality control sites and affects its stability and splicing function.

This study shows that yeast splicing defects cause genome instability through gene expression changes and R-loop accumulation, which is worsened by loss of Mad1.