Jana Wolf

The paper analyzes a mathematical model of coupled muscle stem cells to study how parameters affect stability and oscillatory dynamics in the Hes1-Dll1 regulatory network.

The paper quantifies gene expression noise in mammalian cells using single-cell proteomics and finds that noise is largely extrinsic and structured across cellular states.

The paper develops a computational model to analyze how MYCN-induced expression changes affect energy metabolism in neuroblastoma, revealing Warburg-like flux alterations and potential metabolic bistability.

The paper develops a kinetic model of cancer metabolism that incorporates cellular growth, showing differences in control properties compared to models without growth.

The paper develops a computational model of the DNA damage-induced IKK/NF-κB pathway to analyze how irradiation dose and PARP-1 influence pathway activation.

The paper identifies a long-term multipotent progenitor niche in the hepato-pancreato-biliary system using computational modeling and lineage tracing.

LoopDetect identifies feedback loops in ODE models across MATLAB, Python, and R, supporting parameter ranges and user-defined states.

The paper compares different A20 feedback implementations in NF-κB signaling models to determine their impact on dynamics, finding that one model aligns with experimental data.