Author

Martijn J. van Hemert

Leiden University Medical CenterORCID 0000-0002-2617-9243Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:gene regulatory network inference· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

Eric J. SnijderiD· 2 shared A. Spruit· 1 shared Ali TaşiD· 1 shared Almudena Ponce-SalvatierraiD· 1 shared Annemarthe G. van der VeeniD· 1 shared Anton Jan van ZonneveldiD· 1 shared Arnoud H. de RuiD· 1 shared Bart J.M. GrijmansiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMolecular Biology

Eric J. SnijderORCID

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Author profile →

3 papers

Recent·Most cited

Vault RNAs aid viral infection by facilitating nuclear export of hnRNP C and ELAVL1

Jorn E. Stok, Sander B. van der Kooij, Dennis Gravekamp, Laurens R. ter Haar, Jasper W. de Wolf, Clarisse Salgado‐Benvindo, Tessa Nelemans, Bart J.M. Grijmans, Rayman T.N. Tjokrodirijo, Arnoud H. de Ru, Peter A. van Veelen, Martijn J. van Hemert, Marjolein Kikkert, Annemarthe G. van der Veen

This study shows that vault RNAs enhance viral replication by facilitating the nuclear export of ELAVL1 and hnRNP C, which are required for efficient viral replication.

bioRxiv · Oct 7, 2024 · PreprintMolecular Biology

Highly potent antisense oligonucleotides (ASOs) targeting the SARS-CoV-2 RNA genome

Vita Dauksaite, Ali Taş, Falk Wachowius, A. Spruit, Martijn J. van Hemert, Eric J. Snijder, Eric P. van der Veer, Anton Jan van Zonneveld

ASOs (LNA gapmers) targeting the SARS-CoV-2 RNA genome effectively reduce viral RNA load by up to 96% in vitro.

bioRxiv · Nov 28, 2022 · PreprintMolecular Biology

Genome-wide mapping of therapeutically-relevant SARS-CoV-2 RNA structures

Ilaria Manfredonia, Chandran Nithin, Almudena Ponce-Salvatierra, Pritha Ghosh, Tomasz K. Wirecki, Tycho Marinus, Natacha S. Ogando, Eric J. Snijder, Martijn J. van Hemert, Janusz Marek Bujnicki, Danny Incarnato

This study maps SARS-CoV-2 RNA structures at single-base resolution using SHAPE-MaP, identifies druggable pockets and conserved elements, and highlights targets for antisense therapeutics.

Nucleic Acids Research · Oct 22, 2020Peer-reviewedGenetics