Eric J. Aird

SP110 sequestration of SP100 protects against toxic filaments during innate immune signaling

The paper identifies SP110 as a negative regulator of type 1 interferon-driven cell death by counteracting SP100's toxic filament formation through CARD domain interactions.

Single-stranded HDR templates with truncated Cas12a binding sequences improve knock-in efficiencies in primary human T cells

This study improves CRISPR-Cas12a knock-in efficiency in human T cells by using single-stranded DNA templates with double-stranded Cas-target-sequences, achieving up to 90% knock-in rates for transgene inserts.

Split Staphylococcus aureus prime editor for AAV delivery

This paper describes a split Staphylococcus aureus prime editor delivered by dual AAVs, demonstrating in vitro editing capacity despite lower-than-ideal efficiency.

SNAPS: A toolkit for studying cell surface shedding of diverse transmembrane receptors

The paper introduces SNAPS, a toolkit to study proteolytic switches in transmembrane receptors, identifies new switches, and demonstrates its use in screening and therapeutic testing.

Increasing Cas9-mediated homology-directed repair efficiency through covalent tethering of DNA repair template

This paper enhances HDR efficiency by covalently tethering a donor DNA template to the Cas9/guide RNA complex, achieving up to 8-fold improvement in several editing assays.