Jan M. Deussing

Loss of noradrenergic Fkbp5 disrupts social behavior and norepinephrine dynamics in the basolateral amygdala

This study shows that Fkbp5 in noradrenergic neurons affects social behavior and norepinephrine dynamics in the basolateral amygdala, specifically in male mice.

Neuropeptide CRH prevents premature differentiation of OPCs following CNS injury and in early postnatal development

This study identifies CRH-expressing OPCs that prevent premature differentiation following CNS injury and in early development, highlighting CRHR1's role in oligodendrogenesis.

Molecular and neural mechanisms of behavioural integration in the extended-amygdala

The paper identifies neural ensembles in the extended amygdala of mice that encode diverse behaviours across contexts and links these ensembles to gene expression profiles associated with psychiatric and neurodegenerative disorders.

Tripartite extended amygdala - basal ganglia CRH circuit drives arousal and avoidance behaviour

The paper identifies a novel tripartite CRH circuit connecting extended amygdala and basal ganglia that drives arousal and avoidance behaviour through CRH receptor 1 in the substantia nigra.

The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus

This study investigates the role of Fkbp5 in the paraventricular nucleus of the hypothalamus in shaping the HPA axis stress response through genetic manipulations.

Hypothalamic glucocorticoid receptor in CRF neurons is essential for HPA axis habituation to repeated stressor

The paper shows that glucocorticoid receptors in CRF neurons are essential for HPA axis habituation to repeated stressors by modulating inhibitory tone and dampening activation.

The role of m6A-RNA methylation in stress response regulation

This paper investigates how m6A RNA methylation in the brain is regulated by stress and shows its role in fear memory, transcriptome response, and synaptic plasticity, with implications for stress-related disorders.