Nicolas S. Buchon

This study identifies Upd as an activator of JAK/STAT signaling in mosquitoes that restricts arbovirus infection and reduces vector competence.

This study uses Drosophila midgut to investigate SARS-CoV-2-induced gastrointestinal pathogenesis, finding disrupted epithelial architecture, altered lipid homeostasis, and partial mitigation by Plitidepsin.

This study develops a mathematical model showing that bacterial corpses can influence infection dynamics and immune evolution by both hindering pathogen control and protecting against autoimmune damage.

This study identifies Ugt35B1 as the key enzyme for nicotine glycosylation in Drosophila, revealing an insect detoxification pathway.

This study identifies JAK-STAT signaling and Upd-like as critical for midgut regeneration and infection tolerance in Aedes aegypti.

This study shows that intestinal regrowth after infection depends on diet rather than a fixed size memory, with distinct cellular mechanisms for diet- and infection-induced resizing.

This study examines polarized trafficking of viral envelope proteins in insect midgut and salivary gland cells, finding that specific motifs and host factors mediate directionality in different tissues.

The paper constructs a gene co-expression network for Anopheles gambiae using 257 studies, addressing missing values and analyzing network properties like degree distribution and community structure.

The paper uses computational models to show that host-pathogen feedbacks can lead to divergent infection outcomes, even with similar initial conditions.

This study identifies miR-375 as a key regulator of intestinal crypt homeostasis, showing its role in stem cell proliferation, tuft cell abundance, and resistance to infection and cancer.