Author

Lei Zheng

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cancer Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Angel A. Dominguez· 1 shared Bei LiuiD· 1 shared Boyang WangiD· 1 shared Chang LiuiD· 1 shared Chang YeiD· 1 shared Chengwei ZhouiD· 1 shared Chenhui He· 1 shared Chuan HeiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

Angel A. Dominguez

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Author profile →

3 papers

Recent·Most cited

A glycoRNA switch for malignancy: SNORA73B activates TIAR-dependent oncogenic signaling in lung adenocarcinoma

Lulu Yang, Boyang Wang, Yufei Sheng, Zishun Deng, Jiali Liu, Zhiqi Hong, Lei Zheng, Chengwei Zhou, Wentao Hu, Zhaohui Gong

This study identifies SNORA73B as a glycosylated small nucleolar RNA that promotes lung adenocarcinoma progression through TIAR-dependent oncogenic signaling.

bioRxiv · Jun 23, 2026 · PreprintCancer Biology

m6A-dependent microRNA binding to chromatin-associated RNA for transcriptional activation

Yuhao Zhong, Lei Zheng, Jiahao Li, Chang Liu, Jiangbo Wei, Chang Ye, Xiaoyang Dou, Bei Liu, Elias Barbosa, Fan Yang, Sean P. Pitroda, Mengjie Chen, Ralph R Weichselbaum, Chuan He

The paper reveals an m6A-dependent mechanism where microRNAs bind chromatin-associated RNAs to activate transcription by recruiting chromatin remodelers and demethylases.

bioRxiv · Mar 11, 2026 · PreprintMolecular Biology

NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under environmental stress

Yi Xu, Michael H Nipper, Angel A. Dominguez, Chenhui He, Francis E. Sharkey, Sajid Khan, Han Xu, Daohong Zhou, Lei Zheng, Yu Luan, Jun Liu, Pei Wang

This study identifies NF2 as a critical tumor suppressor in PDAC, showing its role in promoting invasive behavior, enhancing cell fitness under stress, and contributing to drug resistance.

Journal of Clinical Investigation · Jan 1, 2026Peer-reviewedCancer Biology