Author

Isha Sharma

University of California, San FranciscoORCID 0000-0003-3936-914XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Genetic & Genomic Medicine· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Emily L. GoldbergiD· 2 shared Amber N. StratmaniD· 1 shared Anna PiiD· 1 shared Anudari LetianiD· 1 shared Balyn W. ZaroiD· 1 shared Bérénice Anath BenayouniD· 1 shared Claudia Veronica Da Silva CrispimiD· 1 shared Clayton BakeriD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

Emily L. GoldbergORCID

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3 papers

Recent·Most cited

Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth

Anudari Letian, Kyrlia Young, Anna Pi, Michelangelo Bauwelz Gonzatti, Regan F. Volk, Isha Sharma, Clayton Baker, Bérénice Anath Benayoun, Balyn W. Zaro, Amber N. Stratman, Emily L. Goldberg

This study shows that neutrophil TLR2 signaling promotes lipid uptake and storage, contributing to atherosclerotic plaque growth.

bioRxiv · Jul 9, 2025 · PreprintImmunology

AI-Driven Fluorescence Peak Analysis for Chromosomal Aneuploidy Detection: A Python-Based Machine Learning Approach for Enhanced Accuracy and Efficiency

Krishna Himmatbhai Goyani, Daisy Patel, Isha Sharma, Shalin Vaniawala, Pratap N. Mukhopadhyaya

This paper develops an AI-driven method using XGBoost to detect chromosomal aneuploidy in amniotic fluid samples, achieving high accuracy and significantly reducing analysis time.

medRxiv · Mar 22, 2025 · PreprintGenetic & Genomic Medicine

Class I histone deacetylases catalyze lysine lactylation

Takeshi Tsusaka, Mohd Altaf Najar, Isha Sharma, Mariola M. Marcinkiewicz, Claudia Veronica Da Silva Crispim, Nathaniel W. Snyder, George M. Burslem, Emily L. Goldberg

This paper identifies class I HDACs as enzymes that catalyze lysine lactylation, showing that this modification is primarily formed through enzymatic action rather than non-enzymatic pathways.

bioRxiv · Feb 25, 2025 · PreprintBiochemistry