Pharmacology & ToxicologybioRxivPreprint
Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity
Richard T. Eastman, Radda Rusinova, Karl F. Herold…·Jayme L. Dahlin
This study shows ivermectin reduces SARS-CoV-2 viral burden in vitro but at concentrations that also cause cytotoxicity, suggesting its antiviral effect may be due to nonspecific membrane perturbation rather than specific antiviral activity.