Author
Brigham and Women's HospitalORCID 0000-0003-4176-6566Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
David W. Basta, Franz G. Zingl, Yi‐Yan Yang…·Matthew K. Waldor
The paper introduces MultiCAST, a high-throughput CRISPR-associated transposon system for bacterial gene disruption, enabling rapid and scalable genetic screens using amplicon sequencing.
Ian W. Campbell, David W. Basta, Franz G. Zingl…·Matthew K. Waldor
The paper shows that anoxia activates the CRISPR-Cas system in the mouse intestine via the Fnr regulator, suggesting an adaptation for microbial defense.
David W. Basta, Ian W. Campbell, Emily J. Sullivan…·Matthew K. Waldor
InducTn-seq improves transposon mutagenesis by enabling temporal control of transposition, generating diverse mutants and quantifying gene fitness across essential and non-essential genes.