Andrew D. Weems

This study evaluates three septin-targeting compounds' effects on septin structures and viability in melanoma cells, revealing divergent impacts on different septin assemblies.

This paper shows that bleb-induced septin signaling supports survival of metastatic melanoma cells in vivo, and disrupting this pathway reduces metastasis.

The paper introduces u-Segment3D, a tool that converts 2D cell segmentations into 3D consensus segmentations without training data, demonstrating effectiveness across diverse datasets.

The paper introduces u-Unwrap3D to map 3D cell surfaces and analyze interactions between geometry and molecular signals, revealing new dynamics in immune and tumor cell behaviors.

The paper identifies cytosolic chaperone interactions with a tumor-derived p53 mutant using split-YFP in budding yeast, showing temperature-sensitive nuclear exclusion and dominant-negative effects.

The paper shows that guanidine hydrochloride reactivates an ancient septin hexamer assembly pathway in yeast by mimicking a missing arginine sidechain in Cdc3.