Alessandro Vannini

The paper profiles EV-RNA and cfDNA from mCRPC patients to identify prognostic biomarkers and tumor microenvironment signals.

This study uses cryo-EM and single molecule imaging to reveal how M18BP1 activates condensin II to drive DNA compaction during mitosis.

The paper identifies M18BP1 as a factor required for condensin II localization to chromatin and shows it competes with MCPH1 to activate condensin II during mitosis.

The paper presents cryo-EM structures of the SNAPc-containing Pol III PIC on the U6 snRNA promoter and identifies structural differences in SNAPc engagement between Pol III and Pol II PICs.

This study determines the structural basis of RNA polymerase II initiation at snRNA promoters using SNAPc, revealing its role in DNA opening and transcription initiation independent of TFIIE and TFIIH.

The paper shows TFIIIC binding to Alu elements regulates gene expression through chromatin looping and histone acetylation during serum starvation.