Kristina Žumer

The paper reports the cryo-EM structure of a transcribing Pol II-U1 snRNP complex with DSIF and SPT6, showing how phosphorylated Pol II and SPT6 interact with U1 snRNP to facilitate spliceosome assembly and transcription processivity.

This study quantifies mRNA synthesis, nuclear export, and degradation rates genome-wide, finding nuclear export is slow and cytosolic degradation is fast, with some transcripts using alternative export pathways.

This study determines the structural basis of RNA polymerase II initiation at snRNA promoters using SNAPc, revealing its role in DNA opening and transcription initiation independent of TFIIE and TFIIH.