Leonid P. Savtchenko

NEURON-based platform that stochastically adds dendritic spines, astrocyte nanoprocesses and a dynamic extracellular space; example simulations show spines widen input-output range and myelin Kir4.1 sustains high-frequency conduction.

The paper shows that sensory experience increases glutamate release and strengthens synaptic connections in the barrel cortex, leading to changes in the functional connectome.

The paper shows that volume-transmitted GABA waves drive epileptiform rhythms in hippocampal networks by elevating tonic GABAA receptor conductance across multiple cells.

The paper shows that sensory-stimulation LTP increases synaptic fidelity while reducing excitation at thalamocortical connections, generating spatially intersecting glutamate discharges.

The paper shows that postsynaptic NMDA receptor-mediated K+ efflux reduces astrocytic glutamate uptake while enhancing presynaptic glutamate release.

The paper shows that release probability increases with distance from the soma in CA3-CA1 synapses, enhancing signal transfer fidelity at higher frequencies.

The paper shows that extracellular GABA concentration modulates coincidence detection in excitatory circuits by affecting membrane shunting via GAT-1.

The paper constructs a realistic multi-compartmental astrocyte model to explore its biophysical properties and uncover features inaccessible through empirical methods.