Author

Santiago Solé‐Domènech

Weill Cornell MedicineORCID 0000-0002-7988-8983Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Anna Maria PlanasiD· 1 shared Ava KatziD· 1 shared Carles JusticiaiD· 1 shared Christian M. MetalloiD· 1 shared Christina K. Lim· 1 shared Costantino IadecolaiD· 1 shared Estibaliz Capetillo‐ZarateiD· 1 shared Fred H. GageiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Anna Maria PlanasORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Intravital pH Imaging using the sensor ApHID Reveals Incomplete Lysosomal Acidification in Resident Meningeal Phagocytes.

Santiago Solé‐Domènech, Sung Ji Ahn, Michael Iskols, Estibaliz Capetillo‐Zarate, Lucy Funes, Jordi Pedragosa, Carles Justicia, Lynn-Marie Johnson, J. David Warren, Anna Maria Planas, Josef Anrather, Costantino Iadecola, Frederick R. Maxfield

The paper uses ApHID-dextran to measure lysosomal pH in mouse meningeal phagocytes, revealing incomplete acidification and changes under pathological conditions.

bioRxiv · Sep 18, 2026 · PreprintNeuroscience

Impaired lipoprotein secretion by APOE4 leads to lysosomal and mitochondrial dysfunction in human microglia

Jasmin S. Revanna, Karl A. Wessendorf-Rodriguez, Qiang Xiao, Thaís S. Sabedot, Michael S. Cuoco, Snigdha Sarkar, Lucia Zhou-Yang, Christina K. Lim, Victoria N. Prozapas, Rowan S. Wooldridge, Jean Paul Chadarevian, Joshua M. Pratt, Sheila C. Steiner, Ava Katz, Jérôme Mertens, , Fred H. Gage

This study shows that APOE4 impairs lipoprotein secretion in microglia, leading to lysosomal and mitochondrial dysfunction and a proinflammatory phenotype.

bioRxiv · May 13, 2026 · PreprintNeuroscience