Anna Maria Planas

Intravital pH Imaging using the sensor ApHID Reveals Incomplete Lysosomal Acidification in Resident Meningeal Phagocytes.

The paper uses ApHID-dextran to measure lysosomal pH in mouse meningeal phagocytes, revealing incomplete acidification and changes under pathological conditions.

Defensive lipid droplets are PUFA reservoirs driving bacterial clearance and inflammation

The paper shows that lipid droplets store polyunsaturated fatty acids (PUFAs) that are critical for bacterial clearance and inflammation by macrophages.

Age-dependent lipid droplet-rich microglia worsen stroke outcome in old mice

This study shows that age-dependent lipid droplet-enriched microglia worsen stroke outcomes in old mice by exacerbating immune responses and metabolic disturbances.

Clemastine induces an impairment in developmental myelination

This study shows clemastine increases oligodendrocyte differentiation but impairs myelination during development, likely due to microglia-oligodendrocyte interactions.

Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality

This study examines how a major genetic risk factor for COVID-19 affects mortality and severity, finding stronger effects in younger adults.