Amanda A. Hewes

This study examines retinal aging across nine genetically diverse mouse strains, identifying molecular aging signatures and validating WSB and NZO as models for retinal neurodegenerative diseases.

This study shows that microglia depletion in aged mice increases optic nerve damage in glaucoma models, suggesting microglia protect against ocular hypertension-induced retinal ganglion cell loss.

This study shows that metabolic syndrome in NZO mice reduces microglial plasticity and increases vascular interactions compared to B6J mice.

The paper shows genetic context influences microglia-synaptic interactions in AD mouse models, with differential effects in B6 and PWK strains.

This study shows that APOEϵ4 genotype interacts with exercise to influence systemic and cerebral risk factors for dementia in mice, with sex-specific effects on metabolism, brain function, and aging.