Paracrine Bone-Derived Senescent Secretome Induces Spatially Patterned ECM and Biomechanical Vulnerability in Human Brain Organoids
Chanul Kim, Luke Daniel Ofria, Anannya Kshirsagar…·Maryam Tilton
This study shows that senescent bone cells' secretome causes spatially varied ECM changes and mechanical weakness in human brain organoids.