John Joseph McCarthy

The paper identifies age-related differences in the transcriptional states of MuSC-derived myonuclei in response to mechanical overload.

This study examines age-related differences in myonuclear multi-omic responses to muscle hypertrophy in mice, identifying transcriptional, epigenetic, and regulatory mechanisms underlying age-dependent muscle plasticity.

This study shows miR-1 regulates metabolic flexibility in skeletal muscle by controlling pyruvate metabolism, with loss of miR-1 causing metabolic inflexibility and reduced endurance.

The paper investigates how resistance exercise and mechanical overload upregulate vimentin in skeletal muscle, linking it to hypertrophy and regeneration.

The paper shows that microbial-derived exerkines from exercise-trained mice prevent skeletal muscle atrophy in a hindlimb-immobilization model.