Christopher Brooks Mobley

Exogenous L6 myotube mitochondrial transplantation attenuates hypertrophy and elicits a unique proteomic signature in phenylephrine-treated H9C2 cardiomyocytes

This study shows that transplanting L6 myotube mitochondria reduces hypertrophy and alters proteomic pathways in phenylephrine-treated H9C2 cardiomyocytes.

Aging concomitantly reduces skeletal muscle proteome plasticity and hypertrophic responses to resistance training

This study shows aging reduces proteome plasticity and hypertrophic responses to resistance training in skeletal muscle, but RT partially reverses some aging-related changes.

Acute molecular and chronic vastus lateralis adaptations to lengthened partial versus full range of motion resistance training in previously trained males

This study compares acute and chronic adaptations in vastus lateralis muscle from lengthened partial versus full range of motion resistance training in trained males, finding similar outcomes but potential hamstring differences.

Resistance training-induced appendicular lean tissue mass changes are largely unrelated to pre-training bone characteristics in a larger cohort of untrained adults

This study examines if pre-training bone characteristics predict changes in lean tissue mass after resistance training, finding little association.

Proteomic profiling of skeletal muscle ribosomes from higher versus lower responders to 10 weeks of resistance training

This study develops a ribosome enrichment protocol for human muscle tissue and examines ribosomal protein composition differences between higher and lower responders to resistance training.

Leg immobilization and subsequent recovery resistance training affect skeletal muscle angiogenesis related markers in young healthy adults regardless of prior resistance training experience

This study examines how leg immobilization and recovery resistance training affect skeletal muscle angiogenesis markers in young adults, finding similar molecular responses regardless of prior training experience.

Resistance Exercise and Mechanical Overload Upregulate Vimentin for Skeletal Muscle Remodeling

The paper investigates how resistance exercise and mechanical overload upregulate vimentin in skeletal muscle, linking it to hypertrophy and regeneration.

Effects of leg immobilization and recovery resistance training on skeletal muscle-molecular markers in previously resistance trained versus untrained adults

This study examines how resistance training status affects muscle size and molecular markers during leg immobilization and recovery training in young adults.

Skeletal muscle ribosome analysis: a comparison of common assay methods and utilization of a novel RiboAb antibody cocktail

The paper compares RNA quantification methods for ribosome content in skeletal muscle and evaluates a novel RiboAb antibody cocktail as a surrogate for rRNA levels.

Skeletal muscle myosin heavy chain protein fragmentation as a potential marker of protein degradation in response to resistance training and disuse atrophy

This study examines how resistance exercise and disuse atrophy affect myosin heavy chain (MyHC) protein fragmentation in humans, finding increased fragmentation post-exercise and during atrophy, with adaptive responses after training.

Microbial-Derived Exerkines Prevent Skeletal Muscle Atrophy

The paper shows that microbial-derived exerkines from exercise-trained mice prevent skeletal muscle atrophy in a hindlimb-immobilization model.

Relative rDNA copy number is not associated with resistance training-induced skeletal muscle hypertrophy and does not affect myotube anabolism in vitro

This study investigates the relationship between relative rDNA copy number and resistance training-induced skeletal muscle hypertrophy, finding no significant association.

Resistance Training Diminishes Mitochondrial Adaptations to Subsequent Endurance Training

This study examines how resistance training before endurance training affects mitochondrial adaptations, finding that prior resistance training impairs mitochondrial responses to subsequent endurance training.

Skeletal muscle DNA methylation and mRNA responses to a bout of higher versus lower load resistance exercise in previously trained men

This study compares DNA methylation and mRNA responses to lower- versus higher-load resistance exercise in trained men, finding similar gene expression and methylation patterns despite differences in exercise intensity.