Yuan Wen

This study shows human circTau 12->7 RNA is translated in mouse neurons and causes tau aggregation, suggesting it may contribute to Alzheimer's disease.

This study shows light-cycle time-restricted feeding alters cardiac transcript usage in a sex-specific manner, revealing previously undetected transcript-level regulation.

The paper shows that exercise preconditioning enhances skeletal muscle hypertrophy through epigenetic and metabolic changes, specifically involving Smox and Wnt signaling.

The paper identifies age-related differences in the transcriptional states of MuSC-derived myonuclei in response to mechanical overload.

This study shows that housing mice in thermoneutrality alters tissue-specific circadian gene expression without changing core clock genes.

The paper shows that transient MYC activation in skeletal muscle mimics exercise-induced adaptations, leading to hypertrophy, metabolic changes, and fiber type shifts.

This study uses 3D-imaging to assess intrinsic contractile function in aging human skeletal muscle fibers, finding preserved function despite reduced fiber size.

This study examines age-related differences in myonuclear multi-omic responses to muscle hypertrophy in mice, identifying transcriptional, epigenetic, and regulatory mechanisms underlying age-dependent muscle plasticity.

This study shows miR-1 regulates metabolic flexibility in skeletal muscle by controlling pyruvate metabolism, with loss of miR-1 causing metabolic inflexibility and reduced endurance.

This study maps the 24-hour molecular response to resistance exercise in human muscle, identifying MYC as a key regulator of hypertrophy and mRNA levels.

The paper shows that microbial-derived exerkines from exercise-trained mice prevent skeletal muscle atrophy in a hindlimb-immobilization model.