The paper identifies migratory non-canonical AT2 cells in IPF lung fibrosis, showing they are trapped in developmental transition states that drive fibrosis progression.

bioRxiv · Feb 17, 2026 · PreprintCell Biology

Maternal Western-style Diet Promotes Immune Tolerance and Liver Sinusoidal Endothelial Cell Dysfunction in Nonhuman Primate Juvenile Offspring Liver

Michael J. Nash, Benjamin N. Nelson, Molly Mae McGuckin, Rachel C. Janssen, Kenneth L Jones, Saif I. Al‐Juboori, Evgenia Dobrinskikh, Paul Kievit, Kjersti Marie Aagaard, Carrie E. McCurdy, MAUREEN A. GANNON, Stephanie R. Wesolowski, Jacob E. Friedman

This study shows that maternal Western-style diet during pregnancy and lactation alters immune and endothelial cell function in juvenile nonhuman primate offspring livers, promoting immune tolerance and fibrosis.

bioRxiv · Jan 7, 2026 · PreprintImmunology

Altered Metabolism and DAM-signatures in Female Brains and Microglia with Aging

Nicholas R W Cleland, Garrett J. Potter, Courtney E. Buck, Daphne Quang, Dean Oldham, Mikaela C. Neal, Anthony J. Saviola, Christy S. Niemeyer, Evgenia Dobrinskikh, Kimberley D. Bruce

This study investigates age- and sex-related metabolic changes in female brains and microglia, finding that estrogen may suppress disease-associated microglia (DAM) factors, potentially increasing Alzheimer's disease risk in post-menopausal women.

Brain Research · Apr 1, 2024Peer-reviewedNeuroscience