Stephen Adams

Orthogonally targeted tumor radiosensitization using cell penetrating peptide-ATM inhibitor conjugates to stimulate anti-tumor immune responses

This paper develops a targeted radiosensitizer drug conjugate that enhances tumor control and immune responses while minimizing toxicity to normal tissues.

ColorSTEM: An easy and convenient approach to Multicolor Electron Microscopy of Labeled Biological Specimens

ColorSTEM improves multicolor electron microscopy by using metal-conjugated DAB to enhance signal and simplify imaging.

Directed evolution of the multicopper oxidase laccase for cell surface proximity labeling and electron microscopy

This study evolves a laccase enzyme for cell surface labeling and EM, showing it can map T cell surface changes and visualize cell features without toxic H2O2.

Do perineuronal nets stabilize the engram of a synaptic circuit?

The paper investigates whether perineuronal nets (PNNs) stabilize synaptic circuits and engram formation through high-resolution imaging and experimental approaches.

DOPAL initiates αSynuclein-mediated impaired proteostasis in neuronal projections leading to enhanced vulnerability in Parkinson's disease.

This study shows DOPAL promotes αSynuclein accumulation and impairs proteostasis in neuronal projections, contributing to Parkinson's disease progression.

Elemental Mapping of Labeled Biological Specimens at Intermediate Energy Loss in an Energy-Filtered TEM acquired using a Direct Detection Device

The paper demonstrates improved signal-to-noise and resolution in EFTEM elemental mapping by using lower energy-loss N4,5 edges instead of core-loss M4,5 edges for lanthanide detection.

A genetic probe for visualizing glutamatergic synapses and vesicles by 3D electron microscopy

The paper develops a genetic probe to label and image glutamatergic synaptic vesicles using 3D electron microscopy and deep learning.