Dionicio R. Siegel

Charting the undiscovered metabolome with synthetic multiplexing implicates ibuprofen-carnitine in myotoxicity

The paper uses synthetic multiplexing to annotate uncharacterized metabolites, identifying ibuprofen-carnitine as a metabolite linked to muscle toxicity.

A Multi-Organ Murine Metabolomics Atlas Reveals Molecular Dysregulations in Alzheimer's Disease

The paper presents a multi-organ metabolomics atlas in AD mouse models, identifying dysregulated metabolites and microbiome associations linked to oxidative stress and cognitive impairment.

MS/MS Mass Spectrometry Filtering Tree for Bile Acid Isomer Annotation.

This paper introduces a mass spectrometry filtering tree to distinguish bile acid isomers in LC-MS/MS data and identifies a novel deoxycholyl-2-aminophenol amidate linked to whole grain consumption.

The microbiome diversifies N-acyl lipid pools - including short-chain fatty acid-derived compounds

The paper creates a spectral library of N-acyl lipids from metabolomics data, identifies novel compounds, and links them to health conditions like HIV and cognitive impairment.

Mapping The Malaria Parasite Drug-Able Genome Using In Vitro Evolution And Chemogenomics

Whole genome sequencing reveals how Plasmodium falciparum evolves resistance to diverse compounds and identifies new antimalarial drug targets.