Author

Ayako Isomura-Matoba

RIKEN Center for Biosystems Dynamics ResearchORCID 0000-0002-8518-9329Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Neuroscience· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Ayano OiiD· 1 shared Chisako SakumaiD· 1 shared Dooseon ChoiD· 1 shared Fumiaki ObataiD· 1 shared Henrik SkibbeiD· 1 shared Hiroto Hakamada· 1 shared Itoshi NikaidoiD· 1 shared Masayuki MiuraiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperPhysiology

Ayano OiORCID

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3 papers

Recent·Most cited

A reabsorption mechanism in Drosophila renal tubules maintains amino acid homeostasis

Ayano Oi, Pattama Wiriyasermkul, Hiroto Hakamada, Ayako Isomura-Matoba, Miyu Kubota, Dooseon Cho, Osamu Nishimura, Yusuke Kato, Chisako Sakuma, Takefumi Kondo, Shushi Nagamori, Masayuki Miura, Fumiaki Obata

This study identifies an amino acid reabsorption mechanism in Drosophila Malpighian tubules that maintains systemic amino acid homeostasis despite their primary role in secretion.

bioRxiv · May 11, 2026 · PreprintPhysiology

Migrating mesoderm cells self-organize into a dynamic meshwork structure during chick gastrulation

Yukiko Nakaya, Mitsusuke Tarama, Sohei Tasaki, Ayako Isomura-Matoba, Tatsuo Shibata

The paper shows mesoderm cells form a dynamic meshwork during chick gastrulation, supported by N-cadherin adhesion, which facilitates collective migration.

eLife · Aug 21, 2025Peer-reviewedDevelopmental Biology

Distinctiveness and continuity in transcriptome and connectivity in the anterior-posterior axis of the paraventricular nucleus of thalamus

Yasuyuki Shima, Henrik Skibbe, Yohei Sasagawa, Noriko Fujimori, Yoshimi Iwayama, Ayako Isomura-Matoba, Minoru Yano, Takumi Ichikawa, Itoshi Nikaido, Nobutaka Hattori, Tadafumi Kato

This study identifies four cell types in the mouse PVT using single-cell RNA sequencing and shows their transcriptomic continuity along the anterior-posterior axis, with distinct axon projection patterns and functional responses to neuropeptides.

Cell Reports · Oct 1, 2023Peer-reviewedNeuroscience