Tadafumi Kato

This study uses reversal learning tasks and computational modeling to identify distinct cognitive impairments in mouse models of neurodevelopmental disorders.

The paper sequences the mouse pseudoautosomal region, revealing its structure and evolutionary dynamics.

The paper presents T2T mouse genomes for C57BL/6J and CAST/EiJ, revealing structural diversity in telomeres, centromeres, and key loci like PAR and KZFPs.

This study identifies four cell types in the mouse PVT using single-cell RNA sequencing and shows their transcriptomic continuity along the anterior-posterior axis, with distinct axon projection patterns and functional responses to neuropeptides.

The paper investigates brain pH and lactate levels in animal models of neuropsychiatric disorders, finding decreased pH and increased lactate levels as common features across multiple models.

The paper identifies hypermethylation of SLC6A4 in male schizophrenia patients and links it to reduced amygdala volume and 5-HTTLPR genotype.

The paper shows that polygenic scores for depression traits predict lithium response in bipolar disorder patients, with lower genetic load linked to better treatment outcomes.

This study finds that a higher genetic risk for schizophrenia is linked to poorer lithium response in bipolar disorder patients, suggesting potential for personalized treatment strategies.