Kenzo Ivanovitch

This paper develops a method to analyze tissue motion and deformation during mammalian organogenesis using live imaging data of heart development.

The paper tracks mesodermal cell migration and lineage during mouse gastrulation, revealing distinct progenitor behaviors and fate allocation in cardiac development.

The paper identifies two distinct cis regulatory strategies used by CREs to translate graded Shh signaling into differential gene expression in neural progenitors.

The paper identifies spatial and molecular differences in cardiac progenitor origins in mouse embryos, showing distinct regions of the primitive streak contribute to different heart structures.

The paper challenges the established model of neural induction by showing that cells commit to anterior or posterior regional identities before acquiring neural identity.

The paper uses live imaging of mouse embryos to show that heart tube development involves alternating phases of cardiac differentiation and morphogenesis.