Intranasal sertraline for the investigation of nose-to-brain delivery to mitigate systemic exposure
Shoshana C. Williams, Travis C. Lantz, Vanessa M. Doulames, Alakesh Alakesh, Daniel Ramos Mejia, Carolyn K. Jons, Zi Yi Stephanie Huang, Noah Eckman, Eric Andrew Appel
This study develops intranasal sertraline formulations to reduce systemic exposure while maintaining brain delivery, showing comparable brain exposure at half the dose compared to oral administration in mice.
ACS Pharmacology & Translational Science · Sep 23, 2025Peer-reviewedPharmacology & Toxicology