Michael E. Benros

This study uses forebrain organoids to show that schizophrenia involves sex-specific protein-state dysregulation, with changes in post-translational modifications and proteomic pathways rather than transcript levels.

This study uses patient-derived organoids to identify synaptic protein and phospho-regulatory deficits in schizophrenia.

This study uses brain organoids to show that miRNA dysregulation in schizophrenia leads to premature GABAergic maturation and neurodevelopmental defects.

This study compares guided and unguided forebrain organoids using multi-omic analyses, revealing differences in cellular composition, metabolic profiles, and post-translational modifications.

This paper introduces a haplotype-based framework for heritability estimation and reference-free polygenic prediction, showing improved performance over genotype-based methods in depression and schizophrenia.

This study examines the genetic and phenotypic links between neonatal C3 and C4 protein concentrations and psychiatric and autoimmune disorders, finding no strong causal associations with mental disorders but evidence of lower autoimmune risk with higher C4 levels.

The paper traces the evolutionary history of the CCR5delta32 deletion using ancient and modern genomes, finding it originated at least 7,000 years ago in Western Eurasia and underwent positive selection.

The paper investigates genome-wide interactions between stressful life events and depression using a case-cohort study, identifying three genome-wide significant loci but lacking replication in an independent sample.

This study identifies a bidirectional association between autoimmune and mental disorders using Danish population data and finds HLA loci linked to autoimmune diseases but not mental disorders.