Protein-state dysregulation and sex-specific neurodevelopmental signatures in schizophrenia forebrain organoids
Helle Bogetofte, Sissel Ida Schmidt, Marie Sejberg Øhlenschlæger, Sofie Blomberg Elmkvist, Pia Jensen, Fadumo Abdullahi Mohamed, Anne With Mikkelsen, Elif Bayram Orbe, Jesper Foged Havelund, Matias Ryding, Lucrezia Criscuolo, Lene Andrup Jakobsen, Arkadiusz Nawrocki, Phillip James Robinson, Madeline A. Lancaster, , Martin R. Larsen
This study uses forebrain organoids to show that schizophrenia involves sex-specific protein-state dysregulation, with changes in post-translational modifications and proteomic pathways rather than transcript levels.
bioRxiv · Jun 4, 2026 · PreprintNeuroscience