Tao Zeng

This study uses single-cell multi-omics to analyze transcript isoform and immune repertoire changes in aging human immune cells, identifying age-related molecular features in T cells and B cells.

This study uses complete genomes to model gut microbiome metabolic interactions, revealing ecological group dynamics linked to inflammatory bowel disease and improving disease diagnosis.

The paper presents a comprehensive compendium of fully circularized human gut bacterial genomes and reveals how mobile genetic elements drive functional diversity with therapeutic implications.

FEDRANN improves long-read overlap detection using dimensionality reduction and approximate nearest neighbors, outperforming existing methods on real data.

NanoporeDB is a structural database of multimeric protein nanopores, providing 3D models and quantitative metrics to support nanopore-based sensing and synthetic biology.

The paper creates a single-cell atlas of amniote brains to study cell type diversification and identifies species-specific gene expression patterns and novel cell subtypes.

The paper evaluates CycloneSEQ long-read sequencing for improving bacterial genome assemblies, showing it can produce complete circular genomes when combined with short-read data.

The paper constructs a near-complete genome assembly for the bearded dragon Pogona vitticeps and characterizes the Z sex chromosome, identifying key genes involved in sex determination.

The paper uses single-cell long-read transcriptome sequencing to study transcript diversity and alternative splicing in zebrafish embryos, identifying cell populations with distinct splicing regulations during early development.

The paper presents a telomere-to-telomere genome assembly for Oryza longistaminata, revealing structural variations and gene duplications that may contribute to its advantageous traits.

This paper introduces an improved nanopore sequencing platform called CycloneSEQ, demonstrating long-duration sequencing and high yield with applications in genomics.