Elena Ciirdaeva

The paper identifies localized mRNAs and proteins in cortical layer 1 synapses, showing specialized transcriptomes and suggesting local translation supports layer-specific functions.

The paper presents a chromosome-scale genome assembly of the common cuttlefish Sepia officinalis, revealing its true karyotype and identifying cephalopod-specific gene expansions.

The paper identifies a direct interaction between postsynaptic proteins and ribosomes, revealing a localized synaptic translatome that preferentially translates PSD-related mRNAs.

The paper integrates transcriptomic and proteomic data from mouse hippocampal regions and synapses to reveal molecular diversity and co-regulation patterns.

The paper shows that ribosome biogenesis factors and pre-rRNA processing enzymes are present in distal neuronal compartments, suggesting local ribosome maturation occurs in dendrites.

This study identifies POMP as a stress-induced transcriptional regulator that buffers proteasome dysfunction through a non-canonical role in nucleolar RNA processing.

The paper shows that monosomes, not polysomes, are the main sites of active translation for synaptic mRNAs in neuronal processes, contributing to local protein synthesis.