Reta Birhanu Kitata

Improved surfactant-assisted one-pot sample preparation for robust convenient single cell proteomics

This paper introduces an improved single-cell proteomics method, iSOP-MS, which enhances robustness and convenience for quantitative analysis by using a low-volume 384-well plate and optimized enzyme mixtures.

Enhancing Sensitivity in Targeted Single-Cell Proteomics by Coupling a Dual Ion Funnel Interface with Triple Quadrupole Mass Spectrometer

This paper develops a dual ion funnel interface to enhance sensitivity in single-cell proteomics, enabling reliable quantification of low-abundance proteins from single-cell samples.

Single-cell nanodroplet processing proteomics pipeline for analysis of human-derived microglia

This paper introduces a single-cell proteomics pipeline for analyzing human microglia, identifying 1039 proteins per cell and revealing mitochondrial protein variation across subtypes.

Long-read RNA-seq atlas of novel microglia isoforms elucidates disease-associated genetic regulation of splicing

The paper presents a long-read RNA-seq atlas of microglia isoforms, identifying novel isoforms and their associations with genetic risk loci in Alzheimer's and Parkinson's disease.

Robust collection and processing for label-free single voxel proteomics

This paper introduces a method for label-free single voxel proteomics using wcSOP, enabling spatial resolution of protein expression in tissue samples.

Standardization and Harmonization of Distributed Multi-National Proteotype Analysis supporting Precision Medicine Studies

This paper standardizes a proteotype analysis workflow across multiple international sites to enable distributed, reproducible proteomic data generation for precision medicine.