Lewis R Depaauw-Holt

This study shows that lipid droplet lipolysis in POMC neurons regulates energy homeostasis, with sex-specific effects on body weight and metabolism.

The paper shows low testosterone increases anxiety by altering astrocytic mitochondrial structure and function at the nucleus accumbens blood-brain barrier in rats.

The paper identifies neuronal lipid droplets as conserved structures that regulate energy homeostasis with sex-biased effects in flies and mice.

The paper investigates how stress affects activity levels through interactions between orexin neurons and astrocytes, finding that astrocytic glucocorticoid receptors mediate sex-specific changes in neuronal firing and activity.

This study shows early-life stress causes astrocyte dysfunction in mice, leading to anxiety and fear generalization through impaired synaptic plasticity and neural excitability.