Ciaran Murphy‐Royal

This study uses sparse eGFP labeling to compare astrocyte morphology across brain regions and sexes in mice, finding sex-dependent and region-specific changes after early-life stress.

This study shows that lipid droplet lipolysis in POMC neurons regulates energy homeostasis, with sex-specific effects on body weight and metabolism.

The paper identifies neuronal lipid droplets as conserved structures that regulate energy homeostasis with sex-biased effects in flies and mice.

The paper shows that astrocytes in the basolateral amygdala encode threat-induced anxiety across tasks, contrasting with neurons that encode broader behavioral states.

The paper investigates how stress affects activity levels through interactions between orexin neurons and astrocytes, finding that astrocytic glucocorticoid receptors mediate sex-specific changes in neuronal firing and activity.

This study shows that peripheral inflammation reduces D1-MSN excitability in the NAc by increasing microglial engulfment of glutamatergic inputs.

This study shows early-life stress causes astrocyte dysfunction in mice, leading to anxiety and fear generalization through impaired synaptic plasticity and neural excitability.

This paper develops a genetically encoded fluorescent biosensor for extracellular L-lactate and demonstrates its use in imaging in cultured mammalian cells and brain tissue.

This study shows that obesity impairs astrocyte function in the orbitofrontal cortex, leading to synaptic deficits that are reversed by N-acetylcysteine.