Lucas Kuhlen

Structures and molecular mechanisms of RAD54B in modulating homologous recombination

This paper defines the role of RAD54B in homologous recombination using cryo-EM and biochemical assays, showing it stabilizes RAD51 filaments and promotes D-loop formation.

RAD51AP1 is a versatile RAD51 modulator

This paper identifies RAD51AP1 as a versatile modulator of RAD51, revealing its role in stabilizing RAD51-ssDNA filaments and promoting strand exchange through multiple binding sites.

Structural control for the coordinated assembly into functional pathogenic type-3 secretion systems

This study reveals the structural control of type-3 secretion system assembly in Salmonella, showing how structural features guide the formation of a 24:16/15 basal body and regulate protein secretion.

Structure of the Core of the Type Three Secretion System ExportApparatus

The paper determines the structure of the T3SS export gate core using cryo-EM, revealing a helical assembly with 5:4:1 stoichiometry and identifying it as a key component of the secretion channel.