Galit Alter

Limited O-specific polysaccharide (OSP)-specific functional antibody responses in young children with Shigella infection in Bangladesh

This study examines antibody responses to Shigella in Bangladeshi children, finding that younger children have less effective functional antibody responses against OSP and proteins, correlating with disease severity.

Antibody Correlates of Resilience to Staphylococcus aureus Disease and Recurrence in Children

The paper profiles antibody responses in children to identify correlates of resilience to Staphylococcus aureus disease and recurrence, finding that functional antibodies and Fc receptor engagement are key protective factors.

A multivalent mRNA-LNP therapeutic vaccine with broad cross-genotype immunogenicity elicits clearance of HBV infected hepatocytes

This paper develops an mRNA-LNP vaccine, mRNA-1965, that clears HBV-infected hepatocytes in mice by inducing broad immune responses across HBV genotypes.

Distinct antibody-based signatures and functionality distinguish latent and active pediatric tuberculosis

The paper identifies distinct antibody-based signatures and functionalities in latent and active pediatric tuberculosis, highlighting differences in humoral immune responses that may inform diagnostic and therapeutic strategies.

Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction.

This study identifies protective antibodies against Mycobacterium tuberculosis and shows that their Fc-effector function and Fab domains collaborate to restrict infection through immune cell reorganization.

Immune correlates of early clearance of Mycobacterium tuberculosis among tuberculosis household contacts in Indonesia

The paper investigates immune correlates of early Mtb clearance in TB household contacts, finding that BCG vaccination is linked to enhanced innate immune responses rather than adaptive immunity.

Markov Field network integration of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques

The paper uses Markov Fields to integrate multi-modal immune data from vaccinated macaques, identifying critical immune interactions and predicting perturbation effects.

Protein structure, a genetic encoding for glycosylation

The paper identifies a relationship between protein structure and glycan structure, introducing a glycoimpact matrix to predict glycosylation patterns and validate it through disease variants and engineered antibodies.