Yoav Ben‐Simon

Hippocampal CA3 forms a two-layer network of molecularly distinct cell types in mice and humans

The paper identifies two molecularly distinct subtypes of CA3 pyramidal neurons in mice and humans, revealing their unique anatomical and functional roles in hippocampal circuits.

A Cross-Species Enhancer-AAV Toolkit for Cell Type-Specific Targeting Across the Basal Ganglia

The paper develops a cross-species enhancer-AAV toolkit for targeting specific cell types in the basal ganglia across species, validated in mouse and macaque.

Evaluating Methods for the Prediction of Cell Type-Specific Enhancers in the Mammalian Cortex

The paper evaluates computational methods for predicting cell type-specific enhancers in the mouse cortex using in vivo validation data and finds that open chromatin and sequence models improve prediction accuracy.

Integrated Classification of Cortical Cells and Quantitative Projectomic Mapping Unveil Organizational Principles of Brain-Wide Connectomes at Single Cell Level

This study integrates molecular and morphological data to classify cortical neurons and map their connectomes, revealing organizational principles of brain-wide networks at the single-cell level.

Enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits

The paper presents an enhancer AAV toolbox for targeting and perturbing striatal cell types and circuits in mice, with validated specificity and cross-species applicability.

A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types

The paper develops a toolkit of transgenic mouse lines and enhancer AAVs for selective targeting of cortical cell populations using transcriptomic and epigenomic data.

epDevAtlas: Mapping GABAergic cells and microglia in postnatal mouse brains

The paper creates high-resolution 3D atlases of postnatal mouse brains and maps changes in GABAergic cells and microglia across development.

Enhancer-AAVs allow genetic access to oligodendrocytes and diverse populations of astrocytes across species

The paper develops AAV-based genetic tools to specifically target astrocytes and oligodendrocytes across species, revealing functional roles in reward-dependent acetylcholine responses.

Saturated reconstruction of living brain tissue

This paper introduces a method for saturated reconstruction of living brain tissue using advanced imaging and deep learning to achieve high-resolution, volumetric analysis of neural structures over time.

Fast, high-throughput production of improved rabies viral vectors for specific, efficient and versatile transsynaptic retrograde labeling

The paper develops a high-throughput method for producing improved rabies viral vectors with enhanced titer, selectivity, and efficiency for transsynaptic labeling in neuronal circuits.

Entorhinal layer 6b subplate neurons govern spatial learning and memory

This study identifies a functional role for entorhinal layer 6b subplate neurons in spatial learning and memory by showing their connectivity and impact on hippocampal activity.