Jingyan He

In utero barcoding of mouse mesoderm reveals the clonal architecture of organ mesenchyme

The paper uses in utero barcoding and single-cell transcriptomics to map clonal relationships in mouse mesoderm-derived tissues, revealing lineage relationships in liver and heart mesenchyme.

Resolving cell lineages and gene functions in the developing mouse gastrointestinal tract using in utero transduction

This study uses in utero lentiviral transduction to resolve clonal relationships and gene functions in developing mouse gut lineages, revealing distinct developmental patterns in mesenchyme and enteric nervous system.

Unbiased profiling of multipotency landscapes reveals spatial modulators of clonal fate biases

The paper profiles clonal landscapes in mouse embryos to reveal spatial modulators of clonal fate biases using single-cell lineage tracing and clone2vec.

Jag1 Insufficiency Disrupts Neonatal T Cell Differentiation and Impairs Hepatocyte Maturation, Leading to Altered Liver Fibrosis

This study shows that Jag1 deficiency in a mouse model of Alagille syndrome leads to impaired liver fibrosis due to defective T cell differentiation and hepatocyte maturation.

Neural Plate Targeting by in Utero NanoinjEction (NEPTUNE) reveals a role for Sptbn2 in neurulation and abdominal wall closure

The paper introduces NEPTUNE, an in utero nanoinjection method to study gene function in mouse embryos, and shows that Sptbn2 silencing causes neural tube defects and embryo resorption.