Huaxin Yu

A molecular clutch governs stator engagement and flagellar torque

The paper identifies a molecular clutch mechanism in Borrelia burgdorferi flagellar motors that controls stator engagement and torque generation through distinct conformational states.

In situ cryo-EM reveals how a flagellar motor transmits high torque

This study uses in situ cryo-EM to reveal how the flagellar motor in Borrelia burgdorferi transmits high torque through mechanical coupling and a split washer-shaped FrbA brace.

Sequential assembly in vivo of the bacteriophage P22 genome translocation channel

The paper determines the in vivo structures of P22 infection intermediates and explains how gp10 templates the sequential assembly of three proteins into a trans-envelope channel for genome translocation.

The human papillomavirus L2 protein in the capsid is an ensemble of related structures poised to exit the virus particle

This study uses cryo-EM and computational methods to model the structure of HPV16 L2 protein within the capsid, revealing its conformational flexibility and positioning for virus entry.

Near-atomic in-situ architecture and membrane-coupled dynamics of the Vibrio cholerae sheathed flagellum

This study determines the near-atomic structure of Vibrio cholerae's sheathed flagellum and reveals its dynamic architecture and membrane-coupled mechanisms.

Structural basis of multimodal adsorption and infection initiation by Vibrio phage Peru-2

This study determines the structure of Vibrio phage Peru-2, revealing its multimodal adsorption strategy and infection mechanism involving tailspikes and interactions with bacterial surfaces.

In-situ structure of the flagellar export apparatus in Borrelia burgdorferi

This study uses cryo-EM to determine the structure of the flagellar export apparatus in Borrelia burgdorferi, revealing its assembly mechanism and role in substrate translocation.

Assembly and glycosylation of Helicobacter pylori sheathed flagella

This study determines the near-atomic structure of H. pylori sheathed flagella using cryo-EM, revealing how flagellins and glycans contribute to filament stability and motility.