Author

Jose A. Aceves-Salvador

Broad InstituteORCID 0000-0002-9161-5945Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:bacteria (other)· 1 Organism:C. elegans· 1 Organism:multiple species· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexander A. SoukasiD· 1 shared Armen I. YerevanianiD· 1 shared Benjamin PetersiD· 1 shared Bree B. AldridgeiD· 1 shared Daniel J. BakeriD· 1 shared Deborah Tan HungiD· 1 shared Diana K. HuntiD· 1 shared Dimitra PouliiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Alexander A. SoukasORCID

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2 papers

Recent·Most cited

Reductive death is averted by an ancient metabolic switch.

Fasih M. Ahsan, Jen F. Rotti, Armen I. Yerevanian, Sinclair W. Emans, Nicole L. Stuhr, Jose A. Aceves-Salvador, Wei Wang, Daniel J. Baker, Dimitra Pouli, Owen S. Skinner, Michael D. Blower, Alexander A. Soukas

The paper identifies reductive stress as a toxicity of biguanides like metformin, showing that fatty acid biosynthesis protects against this effect and could be targeted in cancer.

bioRxiv · Nov 24, 2025 · PreprintMolecular Biology

Massively parallel combination screen reveals small molecule sensitization of antibiotic-resistant Gram-negative ESKAPE pathogens

Megan W. Tse, Meilin Zhu, Benjamin Peters, Efrat Hamami, Julie Chen, Kathleen P. Davis, Samuel Nitz, Juliane Weller, Thulasi Warrier, Diana K. Hunt, Yoelkys Morales, Tomohiko Kawate, Jeffrey L. Gaulin, Jon H. Come, Juan Hernandez-Bird, , Paul C. Blainey

This study uses high-throughput screening to identify small molecules that enhance antibiotic efficacy against multidrug-resistant Gram-negative bacteria.

Proceedings of the National Academy of Sciences · Mar 24, 2025Peer-reviewedMicrobiology