Author

Sierra Lore

Buck Institute for Research on AgingORCID 0009-0002-8446-8411Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Immunology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:machine learning (classical)· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Assay:electronic health records· 1

Frequent Co-Authors

Eric M. VerdiniD· 3 shared Morten Scheibye‐KnudseniD· 2 shared Alan TomusiakiD· 1 shared Andrea Roberts· 1 shared Andreea Cristina AlexandruiD· 1 shared Carlos Galicia AguirreiD· 1 shared Corey Julihn· 1 shared Genesis Vega Hormazabal· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

Eric M. VerdinORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BrainYears: A functional EEG-based brain age clock enables intervention-ready measurements of brain aging

Sierra Lore, Corey Julihn, Paola Telfer, Morten Scheibye‐Knudsen, Eric Verdin

The paper develops an EEG-based brain age clock using machine learning to predict chronological age and assess brain aging, showing a decrease in brain age with intervention.

bioRxiv · Mar 30, 2026 · PreprintBioinformatics

Utilizing blood single-cell transcriptomics to integrate intrinsic and systemic immune aging

Alan Tomusiak, Sierra Lore, Morten Scheibye‐Knudsen, Eric Verdin

This study uses single-cell transcriptomics to analyze immune aging, finding that acute COVID and HIV+ART both increase naive CD8 T cell transcriptomic age.

Aging · Feb 8, 2026Peer-reviewedImmunology

Accumulation of SA-βGal High Cells in Human Naive T Cell Compartments Reveals a Stress-Adapted, Senescent-Like State

Andreea Cristina Alexandru, Genesis Vega Hormazabal, Hiroyuki Matsui, Herbert G. Kasler, Sierra Lore, Carlos Galicia Aguirre, Andrea Roberts, Indra Heckenbach, Ritesh Tiwari, Ryan Kwok, Sydney Becker, Eric M. Verdin

The paper identifies and characterizes SA-βGal-high naive T cells that exhibit senescent-like features but retain proliferative capacity and cytotoxic properties, linking lysosomal-autophagic dysfunction to immune aging and inflammaging.

bioRxiv · Jun 10, 2025 · PreprintImmunology