The paper identifies age-associated Th2-like CD8 memory T cells in human blood and links their accumulation to health conditions like asthma and diabetes.

Aging Cell · Feb 1, 2026Peer-reviewedImmunology

Accumulation of SA-βGal High Cells in Human Naive T Cell Compartments Reveals a Stress-Adapted, Senescent-Like State

Andreea Cristina Alexandru, Genesis Vega Hormazabal, Hiroyuki Matsui, Herbert G. Kasler, Sierra Lore, Carlos Galicia Aguirre, Andrea Roberts, Indra Heckenbach, Ritesh Tiwari, Ryan Kwok, Sydney Becker, Eric M. Verdin

The paper identifies and characterizes SA-βGal-high naive T cells that exhibit senescent-like features but retain proliferative capacity and cytotoxic properties, linking lysosomal-autophagic dysfunction to immune aging and inflammaging.

bioRxiv · Jun 10, 2025 · PreprintImmunology

Regulation of urea cycle by reversible high stoichiometry lysine succinylation

Ran Zhang, Jingqi Fang, Xueshu Xie, Chris Carrico, Jesse G. Meyer, Lei Wei, Joanna Bons, Jacob Rose, Rebeccah R. Riley, Ryan Kwok, Prasanna Vadhana Ashok Kumaar, Yini Zhang, Olga Bielska, Wenjuan He, Yuya Nishida, , Eric M. Verdin

This study identifies high stoichiometry lysine succinylation sites in mouse liver, showing their functional role in urea cycle regulation and ammonia metabolism through SIRT5.

Nature Metabolism · Mar 6, 2024Peer-reviewedMolecular Biology

Chronically disrupted sleep induces senescence in the visceral adipose tissue of C57BL/6J mice

Daria Timonina, Genesis Vega Hormazabal, Indra Heckenbach, Edward Anderton, Lauren Haky, Ariel Floro, Rebeccah R. Riley, Ryan Kwok, Stella Breslin, Harris Ingle, Ritesh Tiwari, Olga Bielska, Morten Scheibye‐Knudsen, Herbert G. Kasler, Judith Campisi, , Eric M. Verdin

This study shows that sleep disruption in mice increases cellular senescence in visceral adipose tissue, leading to oxidative stress and DNA damage, which may accelerate aging and age-related diseases.

bioRxiv · Oct 17, 2023 · PreprintMolecular Biology