Herbert G. Kasler

The paper identifies age-associated Th2-like CD8 memory T cells in human blood and links their accumulation to health conditions like asthma and diabetes.

The paper identifies and characterizes SA-βGal-high naive T cells that exhibit senescent-like features but retain proliferative capacity and cytotoxic properties, linking lysosomal-autophagic dysfunction to immune aging and inflammaging.

This study shows that Zmpste24-/- mice have delayed fracture healing with immune dysregulation and increased cellular senescence compared to wild-type mice.

This study shows that sleep disruption in mice increases cellular senescence in visceral adipose tissue, leading to oxidative stress and DNA damage, which may accelerate aging and age-related diseases.

This study shows CD38 loss increases ovarian NAD+ levels and fecundity in young mice but not in older mice.

The paper develops a novel epigenetic clock, IntrinClock, that measures age-related changes independent of immune cell composition, showing age reversal in reprogramming.

The paper identifies mt-ELP3 as a mitochondrial tRNA modifying enzyme that protects mt-tRNAs from degradation and enhances mitochondrial translation and OXPHOS complex expression.