Ritesh Tiwari

Ketone ester supplementation reduces age-associated B cell activation in aged mice without impairing antibody responses

Multi-omics Analysis of Human Blood Cells Reveals Unique Features of Age-associated Type2 CD8 Memory T cells

The paper identifies age-associated Th2-like CD8 memory T cells in human blood and links their accumulation to health conditions like asthma and diabetes.

Accumulation of SA-βGal High Cells in Human Naive T Cell Compartments Reveals a Stress-Adapted, Senescent-Like State

The paper identifies and characterizes SA-βGal-high naive T cells that exhibit senescent-like features but retain proliferative capacity and cytotoxic properties, linking lysosomal-autophagic dysfunction to immune aging and inflammaging.

Chronically disrupted sleep induces senescence in the visceral adipose tissue of C57BL/6J mice

This study shows that sleep disruption in mice increases cellular senescence in visceral adipose tissue, leading to oxidative stress and DNA damage, which may accelerate aging and age-related diseases.

CD38 regulates ovarian function and fecundity via NAD+ metabolism

This study shows CD38 loss increases ovarian NAD+ levels and fecundity in young mice but not in older mice.

Development of a novel epigenetic clock resistant to changes in immune cell composition

The paper develops a novel epigenetic clock, IntrinClock, that measures age-related changes independent of immune cell composition, showing age reversal in reprogramming.

Human Elp3/Kat9 is a mitochondrial tRNA modifying enzyme

The paper identifies mt-ELP3 as a mitochondrial tRNA modifying enzyme that protects mt-tRNAs from degradation and enhances mitochondrial translation and OXPHOS complex expression.