Genesis Vega Hormazabal

Confident Identification and Quantification of Mouse Brain Tissues Reveals Sirtuin 5-Dependent Regulation

This paper develops a proteomic workflow to confidently identify and quantify lysine methylmalonylation in mouse brain tissue, revealing its regulation by SIRT5 and its role in myelin stability.

Multi-omics Analysis of Human Blood Cells Reveals Unique Features of Age-associated Type2 CD8 Memory T cells

The paper identifies age-associated Th2-like CD8 memory T cells in human blood and links their accumulation to health conditions like asthma and diabetes.

Accumulation of SA-βGal High Cells in Human Naive T Cell Compartments Reveals a Stress-Adapted, Senescent-Like State

The paper identifies and characterizes SA-βGal-high naive T cells that exhibit senescent-like features but retain proliferative capacity and cytotoxic properties, linking lysosomal-autophagic dysfunction to immune aging and inflammaging.

Multiplexed Targeted iprm-PASEF Assays for MALDI Mass Spectrometry Imaging of Lipids, NAD+ 2 , and Related Metabolites in CD38 Knockout Mice

The paper introduces iprm-PASEF, a targeted MSI method, to identify and quantify metabolites and lipids in CD38 knockout mice, showing increased NAD+ and decreased ADPR.

Chronically disrupted sleep induces senescence in the visceral adipose tissue of C57BL/6J mice

This study shows that sleep disruption in mice increases cellular senescence in visceral adipose tissue, leading to oxidative stress and DNA damage, which may accelerate aging and age-related diseases.

CD38 regulates ovarian function and fecundity via NAD+ metabolism

This study shows CD38 loss increases ovarian NAD+ levels and fecundity in young mice but not in older mice.