Author

Hiroyuki Matsui

Buck Institute for Research on Aging

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:flow cytometry· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Eric M. VerdiniD· 4 shared Herbert G. KasleriD· 4 shared Ritesh Tiwari· 4 shared Genesis Vega Hormazabal· 3 shared Rebeccah R. RileyiD· 3 shared Alan TomusiakiD· 2 shared Andreea Cristina AlexandruiD· 2 shared Ariel FloroiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersImmunology

Eric M. VerdinORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Multi-omics Analysis of Human Blood Cells Reveals Unique Features of Age-associated Type2 CD8 Memory T cells

Hiroyuki Matsui, Marlene Cervantes, Mir Mubashir Khalid, Alan Tomusiak, Varun Bhamidipati Dwaraka, Jorge Landgrave-Gómez, Prasanna Vadhana Ashok Kumaar, Qingwen Jia Xiaohan Chen, Jessica Ann Lasky-Su, Jake Stone, Ritesh Tiwari, Ryan Kwok, Shuntaro Ichikawa, Benjamin D Ambrose, Rebeccah R. Riley, , Eric Verdin

The paper identifies age-associated Th2-like CD8 memory T cells in human blood and links their accumulation to health conditions like asthma and diabetes.

Aging Cell · Feb 1, 2026Peer-reviewedImmunology

Accumulation of SA-βGal High Cells in Human Naive T Cell Compartments Reveals a Stress-Adapted, Senescent-Like State

Andreea Cristina Alexandru, Genesis Vega Hormazabal, Hiroyuki Matsui, Herbert G. Kasler, Sierra Lore, Carlos Galicia Aguirre, Andrea Roberts, Indra Heckenbach, Ritesh Tiwari, Ryan Kwok, Sydney Becker, Eric M. Verdin

The paper identifies and characterizes SA-βGal-high naive T cells that exhibit senescent-like features but retain proliferative capacity and cytotoxic properties, linking lysosomal-autophagic dysfunction to immune aging and inflammaging.

bioRxiv · Jun 10, 2025 · PreprintImmunology

CD38 regulates ovarian function and fecundity via NAD+ metabolism

Rosalba Perrone, Prasanna Vadhana Ashok Kumaar, Lauren Haky, Cosmo Hahn, Rebeccah R. Riley, Julia L. Balough, Giuliana Zaza, Bikem Soygur, Kaitlyn Hung, Leandro Prado, Herbert G. Kasler, Ritesh Tiwari, Hiroyuki Matsui, Genesis Vega Hormazabal, Indra Heckenbach, , Eric M. Verdin

This study shows CD38 loss increases ovarian NAD+ levels and fecundity in young mice but not in older mice.

iScience · Sep 15, 2023Peer-reviewedDevelopmental Biology

Development of a novel epigenetic clock resistant to changes in immune cell composition

Alan Tomusiak, Ariel Floro, Ritesh Tiwari, Rebeccah R. Riley, Hiroyuki Matsui, Nicolas Andrews, Herbert G. Kasler, Eric M. Verdin

The paper develops a novel epigenetic clock, IntrinClock, that measures age-related changes independent of immune cell composition, showing age reversal in reprogramming.

bioRxiv · Mar 1, 2023 · PreprintGenomics