Author

Jan Gerhartz

University of BonnORCID 0009-0002-9457-4656Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Radosław P. NowakiD· 3 shared Aaron N. HataiD· 1 shared Abigail Elizabeth SmithiD· 1 shared Alexander Daniel CarliniD· 1 shared Anastasia IgnashkinaiD· 1 shared Anthony John IafrateiD· 1 shared Betül Toker· 1 shared Brian B. LiauiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

Radosław P. NowakORCID

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Author profile →

3 papers

Recent·Most cited

Systematic Targeting of Protein Complexes with Molecular COUPLrs

Diane Yang, Stefan Andrew Harry, Harrison Byron Chong, Neha Khandelwal, Edwin Zhang, Natalie Shannon Nordenfelt, Nicholas J. Chen, Christine Lee, Stefan T. Kaluziak, Elizabeth M. Codd, Samay Trivedi, Magdy Gohar, Giovan McKnight, Dawn R. Mitchell, Maolin Ge, , Liron Bar‐Peled

The paper introduces molecular COUPLrs to systematically target protein complexes, identifying new glue classes and their interactions in cancer cell lines.

Cancer Discovery · Jul 27, 2026Peer-reviewedSystems Biology

Activating p53Y220C with a Mutant-Specific Small Molecule

Xijun Zhu, Woong Sub Byun, Dominika Ewa Pieńkowska, Kha The Nguyen, Mengxiong Wang, Sabin A. Nettles, Sai P. Gourisankar, Nick A. Phillips, Jan Gerhartz, Qixiang Geng, Tian Qiu, Jianing Zhong, Zixuan Jiang, Roman C. Sarott, Stephen M. Hinshaw, , Nathanael S. Gray

This paper develops a small molecule, TRAP-1, that activates mutant p53 by forming a ternary complex with BRD4, leading to p53 target gene upregulation and inhibition of cancer cell growth.

Nature Communications · May 2, 2026Peer-reviewedCancer Biology

ProxiCapture Reveals Context-Dependent CRBN Interactome Landscape of Molecular Glue Degraders

Rubina S. Kazi, H. Bailey, Jan Gerhartz, Varun Jayeshkumar Shah, Betül Toker, Julia Bein, Peter Johannes Wild, Radosław P. Nowak, Thorsten Mosler, Ivan Đikić

ProxiCapture identifies context-dependent CRBN interactors of molecular glues across diverse cell types and tissues, revealing a comprehensive atlas of pomalidomide targets.

Disease and Therapeutics · Jan 1, 2026Peer-reviewedCancer Biology