Author

Nicholas J. Chen

Broad InstituteORCID 0000-0002-7975-2787Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 3 Organism:human· 3 Assay:proteomics· 3 Approach:experimental assay· 2 Research Focus:protein design· 2 Research Focus:protein structure prediction· 2 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

Brian B. LiauiD· 3 shared Liron Bar‐PelediD· 3 shared Mariko TakahashiiD· 3 shared Alexander Daniel CarliniD· 2 shared Harrison Byron ChongiD· 2 shared Stefan Andrew HarryiD· 2 shared Aaron N. HataiD· 1 shared Abby E. Smith· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMolecular Biology

Brian B. LiauORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Systematic Targeting of Protein Complexes with Molecular COUPLrs

Diane Yang, Stefan Andrew Harry, Harrison Byron Chong, Neha Khandelwal, Edwin Zhang, Natalie Shannon Nordenfelt, Nicholas J. Chen, Christine Lee, Stefan T. Kaluziak, Elizabeth M. Codd, Samay Trivedi, Magdy Gohar, Giovan McKnight, Dawn R. Mitchell, Maolin Ge, , Liron Bar‐Peled

The paper introduces molecular COUPLrs to systematically target protein complexes, identifying new glue classes and their interactions in cancer cell lines.

Cancer Discovery · Jul 27, 2026Peer-reviewedSystems Biology

Asymmetric Engagement of Dimeric CRL3KBTBD4 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes

Megan J. R. Yeo, Olivia Zhang, Xiaowen Xie, Eunju Nam, N. Connor Payne, Pallavi M. Gosavi, Hui Si Kwok, Irtiza Iram, Ceejay Lee, Jiaming Li, Nicholas J. Chen, Khanh Hung Nguyen, Hanjie Jiang, Zhipeng A. Wang, Kwangwoon Lee, , Ning Zheng

This paper identifies UM171 as a molecular glue that promotes degradation of HDAC1/2 complexes by inducing asymmetric interactions between KBTBD4 and HDAC1.

Nature · Feb 12, 2025Peer-reviewedMolecular Biology

Identification of chemotherapy targets reveals a nucleus-to-mitochondria ROS sensing pathway

Junbing Zhang, Claire M. Simpson, Jacqueline Berner, Harrison Byron Chong, Jiafeng Fang, Zehra Ordulu, Tommy Weiss‐Sadan, Anthony P. Possemato, Stefan Andrew Harry, Mariko Takahashi, Tzu-yi Yang, Marianne Richter, Himani Patel, Abby E. Smith, Alexander Daniel Carlin, , Liron Bar‐Peled

The paper identifies a nucleus-to-mitochondria ROS sensing pathway involving CHK1 and SSBP1 that mediates resistance to platinum-based chemotherapies in ovarian cancers.

bioRxiv · Mar 11, 2023 · PreprintMolecular Biology